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2 edition of NIAID plan for research on immune tolerance found in the catalog.

NIAID plan for research on immune tolerance

National Institute of Allergy and Infectious Diseases (U.S.)

NIAID plan for research on immune tolerance

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Published by NIAID in [Bethesda, Md.] .
Written in English

    Places:
  • United States
    • Subjects:
    • National Institute of Allergy and Infectious Diseases (U.S.),
    • Immunological tolerance -- Research -- United States -- Planning.

    • Edition Notes

      StatementNational Institute of Allergy and Infectious Diseases, National Institutes of Health.
      Classifications
      LC ClassificationsQR188.4 .N38 1998
      The Physical Object
      Pagination31 leaves ;
      Number of Pages31
      ID Numbers
      Open LibraryOL478917M
      LC Control Number98205264

      Plan to Share IPD: Yes: Plan Description: ITNAD (LEAP-On) is a continuation of the ITNAD LEAP Study. The plan is to share data in: 1.) ImmPort, a long-term archive of clinical and mechanistic data from DAIT-funded grants and contracts; and 2.)TrialShare, a clinical trials research portal developed by the Immune Tolerance Network.


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NIAID plan for research on immune tolerance by National Institute of Allergy and Infectious Diseases (U.S.) Download PDF EPUB FB2

Tolerance is the prevention of an immune response against a particular antigen. For instance, the immune system is generally tolerant of self-antigens, so it does not usually attack the body's own cells, tissues, and organs.

However, when tolerance is lost, disorders like autoimmune disease or. Co-sponsored by NIAID and the Juvenile Diabetes Research Foundation International, the ITN is an international consortium of basic scientists and clinical investigators that performs clinical research to evaluate the safety and efficacy of methods that can induce the immune system to tolerate certain antigens for the treatment of immune-mediated.

Get this from a library. The NIAID plan for research on immune tolerance. [National Institute of Allergy and Infectious Diseases (U.S.);]. NIAID will award a cooperative agreement to support clinical research evaluating the safety and efficacy of methods that can induce the immune system to tolerate certain antigens for treating immune-mediated disorders.

The NIAID has a long-standing commitment to supporting basic, translational and clinical research on immune tolerance with the ultimate goal of developing novel, NIAID plan for research on immune tolerance book therapies for the induction and maintenance of antigen-specific immune tolerance in humans.

NIAID will facilitate collaboration and coordination between the Nonhuman Primate Transplant Tolerance Cooperative Study Group and the Collaborative Network for Clinical Research on Immune Tolerance, to be established in the fall of under the cosponsorship of NIAID, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and the Juvenile Diabetes Foundation.

PURPOSE The National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Diabetes NIAID plan for research on immune tolerance book Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), invite applications for exploratory/developmental research project grants to support novel work on the molecular mechanisms and applications NIAID plan for research on immune tolerance book antigen-specific immune tolerance, which is the selective and long-term inactivation of immune.

When blood tests are used to monitor white blood cells, another term for immune cells, a snapshot of the immune system NIAID plan for research on immune tolerance book taken.

If a cell type is either scarce or overabundant in the bloodstream, this may reflect a problem. Thymus: T cells mature in the thymus, a small organ located in the upper chest.

Through both a robust intramural program and investigator-initiated grants and solicited research programs, NIAID supports a strong program to understand basic immune mechanisms, conduct immune profiling, or identify/characterize novel immune cell subsets, pathways, phenomenon, or.

Inthe NIAID initiated a scientific planning process designed to accelerate research in this area. The broad-based, long-range plan, entitled “NIAID Plan for Research on Immune Tolerance”, is available at National Institute of Allergy and Infectious Diseases, NIH: Volume 2: Impact on Global Health covers the scientific aspects of the entire portfolio of NIAID, including microbiology and infectious disease, HIV/AIDS, and immunology and vaccines.

All major diseases and the relevant immunology andBrand: Humana Press. Immune tolerance or immunological tolerance is the process by which the immune system does not attack an antigen. It can be either 'natural' or 'self tolerance', in which the body does.

NIAID is spearheading a $ million initiative to develop new ways of inducing immune tolerance. The strategy promises to improve the success of transplants and treatments for autoimmune diseases. NIAID also supports research on basic immunology, transplantation and immune-related disorders, including autoimmune diseases, asthma and allergies.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers NIAID plan for research on immune tolerance book is a component of the U.S.

Department of Health and Human Services. NIAID 60th Anniversary Timeline. This year, NIAID celebrates 60 years of conducting and supporting basic and applied research to better understand, treat, and ultimately prevent infectious, immunologic, and allergic diseases. Diabetes Technol Ther.

Spring;2(1) NIAID spearheads collaborative network for clinical research on immune tolerance. Klonoff : Klonoff Dc. NIAID Plan for Research on Immune Tolerance () Report of the Expert Panel on Food Allergy Research () Women–s Health in the U.S.: Research on Health Issues Affecting Women ().

Extensive and in-depth, National Institute of Allergy and Infectious Diseases, NIH: Volume 2, Impact on Global Health is a valuable and comprehensive guide providing up-to-date accounts on the state of specific research endeavors in the areas of microbiology and infectious diseases (other than AIDS), HIV/AIDS, allergy, immunology, and.

The Immune Tolerance Network and is sponsored by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. Footer Home.

Evaluation of Immune Response to Vaccines in Primary Immune Disorders I Natural History, Genetics, Phenotype and Treatment of Mycobacterial Infections I: Test New Format - National Institute of Allergy and Infectious Diseases (NIAID) Protocol I The NHPCSG is a multi-center, cooperative research program focused on the study of immune tolerance in non-human primate models of kidney and islet allograft rejection, asthma and allergic diseases and autoimmune diseases.

The NIAID Division of Intramural Research (DIR) conducts basic and clinical research in a wide range of disciplines related to immunology, allergy, and infectious diseases. DIR scientists study all aspects of infectious diseases such as AIDS, malaria, and influenza, including the causative agent, vectors, and pathogenesis in the human host.

Description: This initiative will renew NIAID's successful Immune Tolerance Network (ITN), a consortium of basic and clinical scientists that 1) develops a scientific agenda for clinical trials and mechanistic studies of various approaches to tolerance induction, 2) designs and conducts clinical trials at all phases to determine the feasibility.

The project will link nearly 40 centers around the world in the Collaborative Network for Clinical Research on Immune Tolerance.

The collaborative effort "flows from NIAID's plan to accelerate clinical trials for novel approaches to modulate immune responses," said NIAID Cited by: 2.

The NIAID Primary Immune Deficiency (PID) Clinic is located at the National Institutes of Health (NIH) Clinical Center. The clinic accepts patients who are at least 2 years old who have a known or suspected primary immune deficiency disease.

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol – Sakaguchi S, Yamaguchi T, Nomura T, Ono M Regulatory T cells and immune tolerance.

Cell –Cited by: TrialShare is a transformative approach to data-sharing that enables clinical trial transparency. TrialShare provides clinical trial investigators the unprecedented ability to access de-identified study data, review published analysis methods, and perform real-time, interactive graphical analyses in collaboration with other researchers.

Immune Tolerance Network (ITN) TrialShare shares. NIH-Funded Study Will Test Seasonal Flu Vaccines With Two Experimental Adjuvants, August 8, ; Experimental Treatment Slows Prion Disease, Extends Life of Mice, August 2, ; Clinical Trial to Evaluate Experimental Treatment in People Allergic to Multiple Foods, August 1, New NIAID study examines immune responses in people hospitalized with COVID NIAID Now The Foundation for AIDS Research news, Ap ; NIAID strategic plan details COVID research priorities NIAID/NIH news, Ap ; NIAID Strategic Plan for COVID Research [PDF], Ap ; Expert US panel develops NIH treatment.

The NIAID, Division of Allergy, Immunology, and Transplantation (DAIT) has a requirement for a clinical products center that will obtain, store, and deliver investigational agents to the appropriate clinical trials sites and personnel for DAIT-supported clinical trials, primarily those conducted by the Immune Tolerance Network (ITN).

In Chapter 4, the committee offers recommendations for what specific types of data should be shared and at what times during the life of a clinical trial.

These recommendations are intended to strike a balance between benefiting the public through timely access to data and allowing investigators and sponsors time to complete planned analyses and obtain regulatory approval.

Furthermore, NIAID research in asthma and allergy is supported by studies conducted by several other sponsored initiatives: the Immune Tolerance Network has focused its allergy program on early prevention of peanut allergy and ragweed allergen immunotherapy23, 24; the Consortium in Food Allergy Research conducts observational work and clinical Cited by: The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has awarded approximately $ million to two programs that support research to better understand the human immune response to emerging and re-emerging infectious diseases, including those that may be introduced into a community through acts of bioterrorism.

Physician-Scientist Workforce (PSW) Report ACD Biomedical Workforce Working Group Data Investigators and Trainees Data Book: The NIH-Funded Research Workforce Data Book: NIH Research Training Grants and Fellowships Data Book: Research Career Development Awards.

Innate Immunity to NIAID Category B Protozoa. This initiative will support basic research to define the mechanisms of action by which the innate immune system recognizes and responds to the food and water-borne eukaryotes classified as NIAID Category B priority protozoan pathogens (Cryptosporidium parvum, Cyclospora cayetanensis, Giardia lamblia, Entamoeba histolytica, Toxoplasma, and.

NIAID discovery news. NIAID funding newsletter: The NIAID plan for research on immune tolerance: NIAID report of the Director: NIAID research grand rounds: NIAID sharing best practices seminar series: NIAID's annual fellows workshop: The NIH Medical Research Program Directed Against Chemical Threats: report on research progress and future.

Immune mechanisms of development and strategies for prevention of graft vs. host disease (GVHD), including promotion of graft vs. tumor/leukemia (GVT/GVL) effects. Mechanisms of immune tolerance, both central and peripheral, using a variety of systems including animal models of.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.

Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. the immune system’s job to keep them out or, failing that, to seek out and destroy them.

When the immune system hits the wrong target or is crippled, however, it can unleash a torrent of diseases, including allergy, arthritis, or AIDS.

The immune system is amazingly complex. It can recognize and remember millions of different enemies, and it File Size: 2MB. Identifier: AbaTE - ITNAI TrialShare is the Immune Tolerance Network (ITN) clinical trials research portal that makes data from their clinical trials publicly available without charge.

Study overview and synopsis, -data and reports, -schedule of assessments, -participant flow diagram. Preface. Food allergy is an immune-based disease that has become a serious health concern in pdf United States.

A recent study pdf estimates that food allergy affects 5% of children under the age of 5 years and 4% of teens and adults, and its prevalence appears to be on the increase.

The symptoms of this disease can range from mild to severe and, in rare cases, can lead to anaphylaxis, a severe Cited by: Immunological tolerance is discussed in terms of lymphocytes, the immune cells that provide memory.

The two main types of lymphocytes are B cells, which produce antibodies, and T cells, which.Dean Metcalfe, NIAID. Human Genes that Impact the Mast Cell Ebook Todd Wilson, NIAID.

Mast Cells Regulate Immune Tolerance in Prostate Cancer *FARE Award Winner Stephanie Watkins, NCI. Regulation of Mast Cell Activation by Co-Receptors: Pathological Implications Michael Beaven, NHLBI.